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infection control and hospital epidemiology february 2010, vol. 31, no. 2
shea guideline
Guideline for Disinfection and Sterilization of Prion-Contaminated
Medical Instruments
William A. Rutala, PhD, MPH; David J. Weber, MD, MPH
From Hospital Epidemiology, University of North Carolina Health Care (both authors), and the Division of Infectious Diseases, University of North
Carolina School of Medicine (both authors), Chapel Hill, North Carolina.
Received November 9, 2009; accepted November 19, 2009; electronically published January 6, 2010.
2010 by The Society for Healthcare Epidemiology of America. All rights reserved. 0899-823X/2010/3102-0001$15.00. DOI: 10.1086/650197
epidemiology of the creutzfeldt-
jakob disease prion
Creutzfeldt-Jakob disease (CJD) is a degenerative neurologic
disorder of humans with an incidence in the United States
of approximately 1 case per million population per year.
1-3
CJD is caused by a proteinaceous infectious agent, or prion.
CJD is related to other human transmissible spongiform en-
cephalopathies (TSEs), including kuru (US incidence, 0 [now
eradicated]), Gerstmann-Strau
̈ ssler-Scheinker syndrome (US
incidence, 1 case per 40 million population per year), and
fatal familial insomnia syndrome (incidence,
!
1 case per 40
million population per year). Prion diseases elicit no immune
response, result in a noninflammatory pathologic process
confined to the central nervous system, have an incubation
period of years, and usually are fatal within 1 year after
diagnosis. (continue reading- open link)
shea guideline
Guideline for Disinfection and Sterilization of Prion-Contaminated
Medical Instruments
William A. Rutala, PhD, MPH; David J. Weber, MD, MPH
From Hospital Epidemiology, University of North Carolina Health Care (both authors), and the Division of Infectious Diseases, University of North
Carolina School of Medicine (both authors), Chapel Hill, North Carolina.
Received November 9, 2009; accepted November 19, 2009; electronically published January 6, 2010.
2010 by The Society for Healthcare Epidemiology of America. All rights reserved. 0899-823X/2010/3102-0001$15.00. DOI: 10.1086/650197
epidemiology of the creutzfeldt-
jakob disease prion
Creutzfeldt-Jakob disease (CJD) is a degenerative neurologic
disorder of humans with an incidence in the United States
of approximately 1 case per million population per year.
1-3
CJD is caused by a proteinaceous infectious agent, or prion.
CJD is related to other human transmissible spongiform en-
cephalopathies (TSEs), including kuru (US incidence, 0 [now
eradicated]), Gerstmann-Strau
̈ ssler-Scheinker syndrome (US
incidence, 1 case per 40 million population per year), and
fatal familial insomnia syndrome (incidence,
!
1 case per 40
million population per year). Prion diseases elicit no immune
response, result in a noninflammatory pathologic process
confined to the central nervous system, have an incubation
period of years, and usually are fatal within 1 year after
diagnosis. (continue reading- open link)